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Research Page of Yvan Vander Heyden
Publications with peer review
[1] Y. Vander Heyden, M.S. Khots and D.L. Massart; Three level
screening designs for the optimisation and ruggedness testing
of analytical procedures; Analytica Chimica Acta 276 (1993) 189-195.
(Impact Factor: 1.692)
[2] Y. Vander Heyden; The ruggedness of analytical methods; Analusis,
22 (1994) 27-29. (Impact Factor: 0.550)
[3] C. Hartmann, W. Penninckx, Y. Vander Heyden, P. Vankeerberghen,
D.L. Massart, R.D. McDowall; Experience with Chromatographic Methods
- Europe; Bio-International 2, Bioavailability, Bioequivalence
and Pharmacokinetic Studies; H.H. Blume and K.K. Midha (ed.),
Medpharm Stuttgart (1995) 331-345.
[4] Y. Vander Heyden, K. Luypaert, C. Hartmann and D.L. Massart;
J. Hoogmartens; J. De Beer; Ruggedness tests on the HPLC assay
of the United States Pharmacopeia XXII for tetracycline hydrochloride.
A comparison of experimental designs and statistical interpretations;
Analytica Chimica Acta 312 (1995) 245-262. (Impact Factor:1.692)
[5] Y. Vander Heyden, C. Hartmann and D.L. Massart; L. Michel,
P. Kiechle and F. Erni; Ruggedness tests on an HPLC assay: comparison
of tests at two and three levels by using two-level Plackett-Burman
designs; Analytica Chimica Acta 316 (1995) 15-26. (Impact Factor:1.692)
[6] C. Hartmann, J. Smeyers-Verbeke, W. Penninckx, Y. Vander Heyden,
P. Vankeerberghen and D.L. Massart, Reappraisal of Hypothesis
Testing for Method Validation : Detection of Systematic Error
by Comparing the Means of Two Methods or of Two Laboratories,
Anal. Chem. (1995) 67, 4491-4499. (Impact Factor: 4.580)
[7] S. Boonkerd, M.R. Detaevernier, Y. Vander Heyden, J. Vindevogel
and Y. Michotte; Determination of the enantiomeric purity of dexfenfluramine
by capillary electrophoresis: use of a Plackett-Burman design
for the optimization of the separation; Journal of Chromatography
A, 736 (1996) 281-289. (Impact Factor: 2.321)
[8] Y. Vander Heyden and D.L. Massart; Y. Zhu and J. Hoogmartens;
J. De Beer; Ruggedness tests on the HPLC assay of the United States
Pharmacopeia XXIII for tetracycline hydrochloride : comparison
of different columns in an interlaboratory approach; Journal of
Pharmaceutical and Biomedical Analysis 14 (1996) 1313-1326. (Impact
Factor: 0.914)
[9] Y. Vander Heyden, C. Hartmann and D.L. Massart; P. Nuyten,
A.M. Hollands and P. Schoenmakers; Ruggedness testing of a size
exclusion chromatographic assay for low molecular mass polymers;
Journal of Chromatography A, 756 (1996) 89-106. (Impact Factor:
2.321)
[10] Y. Vander Heyden, D.L. Massart; Review of the use of robustness
and ruggedness in Analytical Chemistry; in A. Smilde, J. de Boer
and M. Hendriks (Eds.) Robustness of analytical methods and pharmaceutical
technological products, Elsevier, Amsterdam, 1996, pp. 79-147
[11] P.F. de Aguiar, Y. Vander Heyden, D.L. Massart, R. Leardi
and J.O. de Beer; Optimization of the isocratic separation of
dithranol and related compounds by Reversed-Phase Liquid Chromatography;
Acta Chromatographica, 7 (1997) 129-148. (Impact Factor: -)
[12] W. Prus, Y. Vander Heyden, P. Kús, D.L. Massart and
T. Kowalska; A statistial evaluation of selected RP-HPLC retention
models; Acta Chromatographica, 7 (1997) 194-209. (Impact Factor:
-)
[13] A. de Juan, Y. Vander Heyden, R. Tauler and D. L. Massart;
Assesment of new constraints applied to the alternating least
squares method; Analytica Chimica Acta 346 (1997) 307-318. (Impact
Factor:1.692)
[14] Y. Vander Heyden, A. Bourgeois and D.L. Massart, Influence
of the sequence of experiments in a ruggedness test when drift
occurs; Analytica Chimica Acta 347 (1997) 369-384. (Impact Factor:1.692)
[15] P.F. de Aguiar, Y. Vander Heyden, Y. Van Oost, T.J. Coomber
and D.L. Massart; Optimisation of the reversed phase liquid chromatographic
separation of atovaquone, proguanil and related substances; J.
Pharm. Biom. Analysis 15 (1997) 1781-1787. (Impact Factor: 0.914)
[16] P.F. de Aguiar, Y. Vander Heyden and D.L. Massart; Study
of different criteria for the selection of a rugged optimum in
HPLC optimisation; Analytica Chimica Acta 348 (1997) 223-235.
(Impact Factor:1.692)
[17] E. Bouveresse, S. Rutan, Y. Vander Heyden, W. Penninckx and
D.L. Massart; Detection, interpretation and correction of changes
in the instrumental response of near-infrared monochromator instruments
over time; Analytica Chimica Acta 348 (1997) 283-301. (Impact
Factor:1.692)
[18] A.T. Bakkali, M. Jaziri, A. Foriers, Y. Vander Heyden, M.
Vanhaelen and J. Homès; Lawsone accumulation in normal
and transformed cultures of henna, Lawsonia inermis; Plant Cell
Tissue and Organ Culture, 51 (1997) 83-87. (Impact Factor: 0.495)
[19] Y. Vander Heyden, F. Questier and D.L. Massart, A ruggedness
test strategy for procedure related factors : experimental set-up
and interpretation; Journal of Pharmaceutical and Biomedical Analysis,
17 (1998) 153-168. (Impact Factor: 0.914)
[20] W. Prus, Y. Vander Heyden, D.L. Massart and T. Kowalska;
Modelling of solute retention in normal-phase HPLC with the chemically
bonded 3-cyanopropyl stationary phase; Acta Chromatographica 8
(1998) 98-107. (Impact Factor: -)
[21] Y. Vander Heyden, F. Questier and D.L. Massart; Ruggedness
testing of chromatographic methods : selection of factors and
levels; Journal of Pharmaceutical and Biomedical Analysis 18 (1998)
43-56. (Impact Factor: 0.914)
[22] J.J.N. Cirunay, Y. Vander Heyden and J. Plaizier-Vercammen;
Separation from Related Compounds and Assay of Calcipotriol by
High-Performance Liquid Chromatography; Journal of Chromatographic
Science 36 (1998) 417-421. (Impact Factor: 1.312)
[23] F. Questier, Y. Vander Heyden and D.L. Massart; RTS, a computer
program for the experimental set-up and interpretation of ruggedness
tests; Journal of Pharmaceutical and Biomedical Analysis 18 (1998)
287-303. (Impact Factor: 0.914)
[24] Y. Vander Heyden, J. Saevels, E. Roets, J. Hoogmartens, D.
Decolin, M.G. Quaglia, W. Van den Bossche, R. Leemans, O. Smeets,
F. Van de Vaart, B. Mason, G.C. Taylor, W. Underberg, A. Bult,
P. Chiap, J. Crommen, J. De Beer, S.H. Hansen and D.L. Massart,
Interlaboratory studies on two HPLC assays for tylosin (tartrate),
Journal of Chromatography A, 830 (1999) 3-28. (Impact Factor:
2.520)
[25] W. Prus, Y. Vander Heyden, P. Vankeerberghen, P. Kús,
D.L. Massart and T. Kowalska, Modelling of solute retention in
the RP-HPLC system with the chemically bonded 3-cyanopropyl stationary
phase, Chemolab 47 (1999) 253-266. (Impact Factor: 1.657)
[26] Y. Vander Heyden, M. Jimidar, E. Hund, N. Niemeijer, R. Peeters,
J. Smeyers-Verbeke, D.L. Massart and J. Hoogmartens; Determination
of system suitability limits with a robustness test, Journal of
Chromatography A 845 (1999) 145-154. (Impact Factor: 2.520)
[27] M.G. Vargas, Y. Vander Heyden, M. Maftouh and D.L. Massart;
Rapid development of the enantiomeric separation of b-blockers
by capillary electrophoresis using an experimental design approach;
J. of Chromatography A 855 (1999) 681-693. (Impact Factor: 2.520)
[28] Y. Vander Heyden, K. De Braekeleer, Y. Zhu, J. Hoogmartens,
J. De Beer and D.L. Massart, Nested designs in ruggedness testing,
Journal of Pharmaceutical and Biomedical Analysis, 20 (1999),
875 - 887. (Impact Factor: 1.010)
[29] C. Vannecke, M. Bloomfield, Y. Vander Heyden and D.L. Massart;
Use of experimental design to optimise a flow injection analysis
assay for L-N-monomethylarginine; Journal of Pharmaceutical and
Biomedical Analysis, 21 (1999) 241-255. (Impact Factor: 1.010)
[30] E. Hund, Y. Vander Heyden, M. Haustein, D.L. Massart and
J. Smeyers-Verbeke, Comparison of several criteria to decide on
the significance of effects in a robustness test with an asymmetrical
factorial design, Analytica Chimica Acta, 404 (2000), 257-271.
(Impact Factor: 1.849)
[31] Y. Vander Heyden, P. Vankeerberghen, M. Novic, J. Zupan and
D.L. Massart; The application of Kohonen neural networks to diagnose
calibration problems in atomic absorption spectrometry; Talanta
51 (2000) 455-466. (Impact Factor: 1.554)
[32] E. Hund, Y. Vander Heyden, M. Haustein, D.L. Massart and
J. Smeyers-Verbeke, Robustness testing of a reversed-phase high-performance
liquid chromatographic assay: comparison of fractional and asymmetrical
factorial designs, J. of Chromatography A, 874 (2000) 167-185.
(Impact Factor: 2.551)
[33] C. Perrin, M.G. Vargas, Y. Vander Heyden, M. Maftouh and
D.L. Massart; Fast development of separation methods for the chiral
analysis of amino acid derivatives using capillary electrophoresis
and experimental designs, J. of Chromatogr. A, 883 (2000) 249-265.
(Impact Factor: 2.551)
[34] S. Toasaksiri, D.L. Massart and Y. Vander Heyden; Study of
method validation criteria in a capillary electrophoresis method
for the separation of non-steroidal anti-inflammatory drugs, Analytica
Chimica Acta 416 (2000) 29-42. (Impact Factor: 1.849)
[35] Y. Vander Heyden, S. Kuttatharmmakul, J. Smeyers-Verbeke
and D.L. Massart; Supersaturated designs for robustness testing;
Analytical Chemistry 72, 13 (2000) 2869-2874. (Impact Factor:
4.587)
[36] C. Vannecke, A. Nguyen Minh Nguyet, M.S. Bloomfield, A. Staple,
Y. Vander Heyden and D.L. Massart, Development and optimisation
of a flow injection assay for fluticasone propionate using an
asymmetrical design and the variable-size simplex algorithm, Journal
of Pharmaceutical and Biomedical Analysis, 23 (2000) 291-306.
(Impact Factor: 1.013)
[37] Y. Vander Heyden, C. Perrin and D.L. Massart, Optimization
strategies for HPLC and CZE, in K. Valko (Ed.), Handbook of Analytical
Separations: Volume 1, Separation Methods in Drug Synthesis and
Purification, Elsevier, Amsterdam (2000) pp. 163-212.
[38] A. Detroyer, V. Schoonjans, F. Questier, Y. Vander Heyden,
A.P. Borosy, Q. Guo and D.L. Massart; Exploratory chemometric
analysis of the classification of pharmaceutical substances based
on chromatographic data, J. of Chromatogr. A, 897 (2000) 23-36
(Impact Factor: 2.551)
[39] V. Schoonjans, F. Questier, Q. Guo, Y. Vander Heyden and
D.L. Massart; Assessing Molecular Similarity/Diversity of chemical
structures by FT-IR spectroscopy, Journal of Pharmaceutical and
Biomedical Analysis 24 (2001) 613-627. (Impact Factor: 1.013)
[40] C.A. De Vriendt, D.K. Van Sassenbrouck, M.T. Rosseel, E.J.
Van De Velde, A.G. Verstraete, Y. Vander Heyden, F.M. Belpaire,
Development and validation of a high-performance liquid chromatographic
method for the determination of gamma-hydroxybutyric acid in rat
plasma, Journal of Chromatography Biomed Applications, 752 (2001)
85-90. (Impact Factor: 1.802)
[41] E. Adams, R. De Maesschalck, B. De Spiegeleer, Y. Vander
Heyden, J. Smeyers-Verbeke and D.L. Massart, Evaluation of dissolution
profiles using principal component analysis, Int. J. Pharm. 212
(2001) 41-53. (Impact Factor: 1.024)
[42] S. Lauwers, Y. Vander Heyden and B. Rombaut; Screening of
an enterovirus specific RT-PCR ELISA method for the quantification
of enterovirus genomes in human body fluids by means of a three-level
experimental design, Journal of Pharmaceutical and Biomedical
Analysis 25 (2001) 131-142. (Impact Factor: 1.013)
[43] Y. Vander Heyden, A. Nijhuis, J. Smeyers-Verbeke, B.G.M.
Vandeginste and D.L. Massart; Guidance for robustness/ruggedness
tests in method validation, Journal of Pharmaceutical and Biomedical
Analysis 24 (2001) 723-753. (Impact Factor: 1.013)
[44] J.J.N. Cirunay, Y. Vander Heyden and J. Plaizier-Vercammen;
LC separation of calcipotriol from its photodegradation products
and protection possibilities using adjuvants; Journal of Pharmaceutical
and Biomedical Analysis, 26 (2001) 31-41. (Impact Factor: 1.013)
[45] F. Estienne, Y. Vander Heyden and D.L. Massart, Chemometrics
and modelling, Chimia 55, 1/2 (2001) 70-80 (Impact Factor: 1.081)
[46] E. Smet, L. Staelens, Y. Vander Heyden, H.Y. Aboul-Enein,
G. Van der Weken, A.M. García-Campaña and W.R.G.
Baeyens; Optimization of the Chiral Separation of 2-arylpropionic
Acids on an Avidin Column by Modelling a Combined Response, Chirality
13, 9 (2001) 556-567. (Impact Factor: 1.603)
[47] C. Perrin, Y. Vander Heyden, M. Maftouh and D.L. Massart;
Rapid screening for chiral separations by short-end injection
CE using highly sulfated cyclodextrins as chiral selectors, Electrophoresis
22 (2001) 3203-3215. (Impact Factor: 3.385)
[48] B. Chimanuka, G. François, G. Timperman, Y. Vander
Heyden, J. Holenz, J. Plaizier-Vercammen, G. Bringmann; A comparison
of the stage-specific efficacy of chloroquine, artemether and
dioncophylline B, against the rodent malaria parasite Plasmodium
chaboudi chaboudi in vivo, Parasitology Research 87 (2001) 795-803.
(Impact Factor: 1.025)
[49] C. Vannecke, E. Van Gijseghem, M.S. Bloomfield, T. Coomber,
Y. Vander Heyden and D.L. Massart; Development of a generic FIA-method
for compounds with a secondary amine or amide function, using
an experimental design approach - I. Selection and evaluation
of the FIA-system parameters, Analytica Chimica Acta 446 (2001)
411-426. (Impact Factor: 1.849)
[50] A. Detroyer, Y. Vander Heyden, S. Carda-Broch, M.C. García-Alvarez-Coque
and D.L. Massart; Quantitative structure-retention and retention-activity
relationships of b-blocking agents by micellar liquid chromatography,
J. Chromatogr. A, 912 (2001) 211-222. (Impact Factor: 2.551)
[51] N. Matthijs, C. Perrin, M. Maftouh, D.L. Massart and Y. Vander
Heyden, Knowledge-based system for method development of chiral
separations with capillary electrophoresis using highly-sulfated
cyclodextrins; Journal of Pharmaceutical and Biomedical Analysis,
27 (2002) 515-529. (Impact Factor: 1.013)
[52] C. Perrin, V.A. Vu, N. Matthijs, M. Maftouh, D.L. Massart
and Y. Vander Heyden, Screening approach for chiral separation
of pharmaceuticals. Part I. Normal phase liquid chromatography,
Journal of Chromatography A, 947 (2002) 69-83. (Impact Factor:2.551)
[53] T. Iványi, Y. Vander Heyden, D. Visky, P. Baten, J.
De Beer, I. Lazar, D.L. Massart, E. Roets and J. Hoogmartens;
A minimal number of chromatographic test parameters for the characterisation
of reversed phase liquid chromatographic stationary phases, Journal
of Chromatography A, 954 (2002) 99-114. (Impact Factor: 2.551).
[54] D. Visky, Y. Vander Heyden, T. Iványi, P. Baeten,
J. De Beer, B. Noszal, E. Roets, D.L. Massart and J. Hoogmartens;
Characterisation of reversed phase liquid chromatographic columns
by chromatographic tests. Preliminary experiments and development
of the protocol, Pharmeuropa, 14.2 (2002) 288-297.
[55] C. Vannecke, M.S. Bloomfield, Y. Vander Heyden and D.L. Massart;
Development of a generic FIA-method for compounds with a secondary
amine or amide function, using an experimental design approach.
Part II: Selection and evaluation of the chemical reaction parameters,
Analytica Chimica Acta 455 (2002) 117-130 (Impact Factor: 1.849)
[56] Y. Vander Heyden, V. Pravdova, F. Questier, L. Tallieu, A.
Scott and D.L. Massart, Parallel co-ordinate geometry and principal
component analysis for the interpretation of large multi-response
experimental designs, Analytica Chimica Acta 458 (2002) 397-415.
(Impact Factor: 1.849)
[57] Y. Vander Heyden, S.T. Popovici and P.J. Schoenmakers; Evaluation
of size exclusion chromatography and size exclusion electrochromatography
calibration curves; Journal of Chromatography A, 957 (2002) 127-137
(Impact Factor: 2.551).
[58] Y. Vander Heyden, A. Nguyen Minh Nguyet, M.R. Detaevernier,
D.L. Massart and J. Plaizier-Vercammen, Simultaneous determination
of ketoconazole and formaldehyde in a shampoo: HPLC method development
and validation; Journal of Chromatography A, 958 (2002) 191-201
(Impact Factor: 2.551).
[59] S. Lauwers, Y. Vander Heyden, B. Rombaut; Screening and optimisation
of an ELISA method for the quantitative detection of enterovirus
specific RT-PCR products by means of a two-level experimental
design; Journal of Pharmaceutical and Biomedical Analysis, 29
(2002) 659-668 (Impact Factor: 1.177)
[60] C. Perrin, N. Matthijs, D. Mangelings, C. Granier-Loyaux,
M. Maftouh, D.L. Massart, Y. Vander Heyden, Screening approach
for chiral separation of pharmaceuticals. Part II. Reversed phase
liquid chromatography, Journal of Chromatography A, 966 (2002)
119-134 (Impact Factor: 2.551).
[61] H.D. Spapen, D.N. Nguyen, K. ver Elst, Y. Vander Heyden and
L.P. Huyghens, N-acetylcysteine and cardiac disfunction in human
septic shock, Clinical Intensive Care Journal, 13, 1 (2002) 27-32.
[62] E. Hund, Y. Vander Heyden, D.L. Massart and J. Smeyers-Verbeke,
Derivation of system suitability test limits from a robustness
test on an LC assay with complex antibiotic samples, Journal of
Pharmaceutical and Biomedical Analysis, 30 (2002) 1197-1206 (Impact
Factor: 1.177).
[63] S. Hillaert, Y. Vander Heyden and W. Van den Bossche; Optimisation
by experimental design of a capillary electrophoretic method for
the separation of several inhibitors of the angiotensin-converting
enzyme using alkylsulphonates; Journal of Chromatography A, 978
(2002) 231-242 (Impact Factor: 2.793).
[64] D. Visky, Y. Vander Heyden, T. Iványi, P. Baten, J.
De Beer, Z. Kovács, B. Noszal, E. Roets, D.L. Massart and
J. Hoogmartens; Characterisation of reversed phase liquid chromatographic
columns by chromatographic tests. Evaluation of 36 test parameters:
repeatability, reproducibility and correlation; Journal of Chromatography
A, 977 (2002) 39-58 (Impact Factor: 2.793).
[65] Y. Vander Heyden, S.T. Popovici, B.B.P. Staal, and P.J. Schoenmakers;
Contribution of the polymer standards' polydispersity to the observed
band broadening in size-exclusion chromatography; Journal of Chromatography
A 986 (2003) 1-15 (Impact Factor: 2.793).
[66] A. Detroyer, Y. Vander Heyden, I. Cambré and D.L.
Massart, Chemometric comparison of recent chromatographic and
electrophoretic methods in a Quantitative Structure-Retention
and Retention-Activity Relationship context, Journal of Chromatography
A, 986 (2003) 227-238 (Impact Factor: 2.793).
[67] E. Van Gyseghem, S. Van Hemelryck, M. Daszykowski, D.L. Massart
and Y. Vander Heyden, Determining orthogonal chromatographic systems
prior to the development of methods to characterise impurities
in drugs, Journal of Chromatography A, 988 (2003) 77-93 (Impact
Factor: 2.793).
[68] R. Put, C. Perrin, F. Questier, D. Coomans, D.L. Massart
and Y. Vander Heyden, Classification and regression tree (CART)
analysis for molecular descriptor selection and retention prediction
in chromatographic QSRR studies, Journal of Chromatography A,
988 (2003) 261-276 (Impact Factor: 2.793).
[69] P. Dehouck, Y. Vander Heyden, J. Smeyers-Verbeke, D.L. Massart,
J. Crommen, P. Hubert, R.D. Marini, O.S.N.M. Smeets, G. Decristoforo,
W. Van de Wauw, J. De Beer, M.G. Quaglia, C. Stella, J.-L. Veuthey,
O. Estevenon, A. Van Schepdael, E. Roets and J. Hoogmartens, Determination
of uncertainty in analytical measurements from collaborative study
results on the analysis of a phenoxymethylpenicillin sample, Analytica
Chimica Acta 481 (2003) 261-272 (Impact Factor: 2.073).
[70] A. Nguyen Minh Nguyet, L. Tallieu, J. Plaizier-Vercammen,
D.L. Massart and Y. Vander Heyden, Validation of an HPLC method
on short columns to assay ketoconazole and formaldehyde in shampoo,
Journal of Pharmaceutical and Biomedical Analysis 32 (2003) 1-19
(Impact Factor: 1.177).
[71] A.M. Van Nederkassel, A. Aerts, A. Dierick, D.L. Massart
and Y. Vander Heyden, Fast separations on monolithic silica columns:
method transfer, robustness and column ageing for some case studies,
Journal of Pharmaceutical and Biomedical Analysis 32 (2003) 233
- 249 (Impact Factor: 1.177).
[72] Y. Vander Heyden, Robuustheidstesten voor biomedische en
farmaceutische analysemethoden (robustness tests for biomedical
and pharamceutical analysis methods), Verhandelingen van de Koninklijke
Academie voor Geneeskunde in België, LXV, 1, (2003) 47-73
(in Dutch).
[73] P. Dehouck, E. Van Looy, E. Haghedooren, K. Deckers, Y. Vander
Heyden, E. Adams, E. Roets and J. Hoogmartens; Analysis of erythromycin
and benzoylperoxide in topical gels by liquid chromatography,
Journal of Chromatography B 794 (2003) 293-302 (Impact Factor:
1.913).
[74] C. Perrin, H. Fabre, M. Maftouh, D.L. Massart and Y. Vander
Heyden, Robustness testing of chiral separations by capillary
electrophoresis using highly-sulfated cyclodextrins, Journal of
Chromatography A 1007 (2003) 165-177 (Impact Factor: 3.098).
[75] C. Perrin, H. Fabre, D.L. Massart, Y. Vander Heyden, Influence
of peak measurement parameters on the quality of chiral electrophoretic
separations, Electrophoresis 24 (2003) 2469-2480 (Impact Factor:
4.325)
[76] D. Mangelings, N. Hardies, M. Maftouh, C. Suteu, D.L. Massart
and Y. Vander Heyden; Enantioseparations of basic and bifunctional
pharmaceuticals in capillary electrochromatography using polysaccharide
stationary phases, Electrophoresis 24 (2003) 2567-2576 (Impact
Factor: 4.325).
[77] P. Dehouck, Y. Vander Heyden, J. Smeyers-Verbeke, D.L. Massart,
R.D. Marini, P. Chiap, Ph. Hubert, J. Crommen, W. Van de Wauw,
J. De Beer, R. Cox, G. Mathieu, C. Reepmeyer, B. Voigt, O. Estevenon,
A. Nicolas, A. Van Schepdael, E. Adams and J. Hoogmartens, Interlaboratory
study of a LC method for erythromycin: Determination of uncertainty,
Journal of Chromatography A 1010 (2003) 63-74 (Impact Factor:
3.098).
[78] D. Visky, Y. Vander Heyden, T. Iványi, P. Baten, J.
De Beer, Z. Kovacs, B. Noszal, P. Dehouck, E. Roets, D.L. Massart
and J. Hoogmartens; Characterisation of reversed-phase liquid-chromatographic
columns by chromatographic tests. Rational column classification
by a minimal number of column test parameters, Journal of Chromatography
A 1012 (2003) 11-29 (Impact Factor: 3.098).
[79] C. Holvoet, J. Plaizier-Vercammen, Y. Vander Heyden, M. Gabriels
and F. Camu, Preparation and in-vitro release of fentanyl-cyclodextrin
complexes for prolonged action in epidural analgesia, International
Journal of Pharmaceutics 265 (2003) 13-26 (Impact Factor: 1.495)
[80] W.R.G. Baeyens, G. Van der Weken, Y. Vander Heyden, V. Van
Bossche, H.Y. Aboul-Enein, A.M. García-Campaña and
E. Smet, Investigation of the Chiral Separation of Cisapride on
Chiralcel OJ and OJ-R Columns, Analytica Chimica Acta 498 (2003)
9-24 (Impact Factor: 2.114).
[81] P. Dehouck, D. Visky, Y. Vander Heyden, E. Adams, Z. Kovács,
B. Noszál, D.L. Massart and J. Hoogmartens; Characterisation
of reversed-phase liquid-chromatographic columns by chromatographic
tests. Comparing column classification based on chromatographic
parameters and column performance for the separation of acetylsalicylic
acid and related compounds, Journal of Chromatography A 1025 (2004)
189-200 (Impact Factor: 3.098).
[82] E. Van Gyseghem, I. Crosiers, S. Gourvénec, D.L. Massart
and Y. Vander Heyden, Determining orthogonal and similar chromatographic
systems from the injection of mixtures in liquid chromatography-diode
array detection and the interpretation of correlation-coefficients
color maps, Journal of Chromatography A 1026 (2004) 117-128 (Impact
Factor: 3.098).
[83] T. Iványi, K. Pál, I. Lázár,
D.L. Massart and Y. Vander Heyden; Application of tetraoxadiaza-crown
ether derivatives as chiral selector modifiers in capillary electrophoresis,
Journal of Chromatography A 1028 (2004) 325-332 (Impact Factor:
3.098).
[84] E. Vasbinder, G. Van der Weken, Y. Vander Heyden, W.R.G.
Baeyens, A. Debunne, J.P. Remon and A.M. García-Campaña,
Quantitative determination of p-aminosalicylic acid and its degradation
product m-animophenol in pellets by ion-pair high performance
liquid chromatography applying the monolithic Chromolith SpeedROD
RP-18e column, Biomedical Chromatography 18 (2004) 55-63 (Impact
Factor: 1.432).
[85] D. Mangelings, C. Perrin, D.L. Massart, M. Maftouh, S. Eeltink,
W. Th. Kok, P.J. Schoenmakers and Y. Vander Heyden; Optimisation
of the chlorthalidone chiral separation by capillary electrochromatography
using an achiral stationary phase and cyclodextrin in the mobile
phase, Analytica Chimica Acta 509 (2004) 11-19 (Impact Factor:
2.114).
[86] A. Detroyer, Y. Vander Heyden, K. Reynaert, D.L. Massart;
Evaluating 'Fast' Micellar Monolithic Liquid Chromatography for
High-Throughput Quantitative Structure-Retention Relationship
Screening, Analytical Chemistry 76 (2004) 1903-1908 (Impact Factor:
5.094).
[87] Y. Vander Heyden, D. Mangelings, J. Van Brempt and H. Spapen;
Development and validation of an HPLC method with post-column
derivatisation to assay N-acetylcysteine in plasma; Acta Chromatographica
14 (2004) 149-164 (Impact Factor: 0.698).
[88] D. Mangelings, M. Maftouh, D.L. Massart and Y. Vander Heyden,
Comparison of the miniaturized techniques capillary electrochromatography
and capillary liquid chromatography for the chiral separation
of chlorthalidone, Journal of Pharmaceutical and Biomedical Analysis,
35 (2004) 789-799 (Impact Factor: 1.425).
[89] N. Matthijs, C. Perrin, M. Maftouh, D.L. Massart and Y. Vander
Heyden, Definition and system implementation of strategies for
method development of chiral separations in NP- or RP-HPLC using
polysaccharide-based stationary phases, Journal of Chromatography
A 1041 (2004) 119-133 (Impact Factor: 2.922).
[90] A. Nguyen Minh Nguyet, A.M. van Nederkassel, L. Tallieu,
S. Kuttatharmmakul, E. Hund, Y. Hu, J. Smeyers-Verbeke and Y.
Vander Heyden, Statistical method comparison: short- and long-column
liquid chromatography assays of ketoconazole and formaldehyde
in shampoo, Analytica Chimica Acta 516 (2004) 87-106 (Impact Factor:
2.210).
[91] E. Van Gyseghem, M. Jimidar, R. Sneyers, D. Redlich, E. Verhoeven,
D.L. Massart and Y. Vander Heyden; Selection of RP-HPLC columns
with diverse selectivity towards the potential separation of impurities
in drugs, Journal of Chromatography A 1042 (2004) 69-80 (Impact
Factor: 2.922).
[92] D. Mangelings, M. Maftouh, D.L. Massart and Y. Vander Heyden,
Chiral separations in reversed-phase capillary electrochromatography:
differences exhibited by normal- and reversed-phase versions of
polysaccharide stationary phases; Electrophoresis 25 (2004) 2808-2816
(Impact Factor: 4.040).
[93] J. Luypaert, S. Heuerding, Y. Vander Heyden and D.L. Massart;
The effect of preprocessing methods in reducing interfering variability
from NIR measurements of creams, Journal of Pharmaceutical and
Biomedical Analysis, 36 (2004) 495-503 (Impact Factor: 1.425).
[94] N. Matthijs, S. Van Hemelryck, M. Maftouh, D.L. Massart,
Y. Vander Heyden, Electrophoretic separation strategy for chiral
pharmaceuticals using highly-sulfated and neutral cyclodextrins
based dual selector systems, Analytica Chimica Acta 525 (2004)
247-263 (Impact Factor: 2.210).
[95] J. Elek, D. Mangelings, F. Joó and Y. Vander Heyden;
Chemometric modelling of the catalytic hydrogenation of bicarbonate
to formate in aqueous media - expectations and results; Reaction
Kinetics and Catalysis Letters 83 (2004) 321-328 (Impact Factor:
0.603).
[96] R. Put, Q.S. Xu, D.L. Massart and Y. Vander Heyden, Multivariate
adaptive regression splines (MARS) in chromatographic quantitative
structure-retention relationship studies, Journal of Chromatography
A 1055 (2004) 11-19 (Impact Factor: 2.922).
[97] P. Dehouck, D. Visky, G. Van den Bergh, E. Haghedooren, E.
Adams, A. Kerner, Y. Vander Heyden, D.L. Massart, Z. Kovacs, B.
Noszal and J. Hoogmartens; Facilitated column ranking and selection
in reversed-phase liquid chromatographic analysis, LC-GC Europe
17 (11) (2004) 592-601 (Impact Factor: 1.194).
[98] A. Detroyer, S. Stokbroeckx, H. Bohets, W. Lorreyne, P. Timmerman,
P. Verboven, D.L. Massart and Y. Vander Heyden, Fast monolithic
micellar liquid chromatography, an alternative drug-permeability
assessing method for high-throughput screening, Anal. Chem. 76
(2004) 7304-7309 (Impact Factor: 5.250).
[99] R.D. Marini, B. Boulanger, Y. Vander Heyden, P. Chiap, J.
Crommen and Ph. Hubert; Uncertainty assessment from robustness
testing applied on an LC assay for R-timolol and related substances
in S-timolol maleate, Analytica Chimica Acta 531 (2005) 131-140
(Impact Factor: 2.210).
[100] D. Mangelings, I. Tanret, N. Matthijs, M. Maftouh, D.L.
Massart and Y. Vander Heyden; Separation strategy for acidic chiral
pharmaceuticals with capillary electrochromatography on polysaccharide
stationary phases, Electrophoresis 26 (2005) 818-832 (Impact Factor:
4.040)
[101] Y. Vander Heyden, D. Mangelings, N. Matthijs and C. Perrin,
'Chiral separations' in "Handbook of HPLC in Pharmaceutical
Analysis", S. Ahuja and M. Dong (Eds.), Academic Press/Elsevier,
2005, pp. 447-498.
[102] Y.B. Ji, Q.S. Xu, Y.H. Hu and Y. Vander Heyden; Development,
optimization and validation of a chromatographic fingerprint of
Ginkgo biloba extracts, Journal of Chromatography A 1066 (2005)
97-104 (Impact Factor: 2.922).
[103] F. Questier, R. Put, D. Coomans, B. Walczak and Y. Vander
Heyden, The use of CART and multivariate regression trees for
supervised and unsupervised feature selection, Chemometrics and
Intelligent Laboratory Systems 76 (2005) 45-54 (Impact Factor:
2.229).
[104] T. Hancock, R. Put, D. Coomans, Y. Vander Heyden, Y. Everingham,
A performance comparison of modern statistical techniques for
molecular descriptor selection and retention prediction in chromatographic
QSRR studies, Chemometrics and Intelligent Laboratory Systems
76 (2005) 185-196 (Impact Factor: 2.229).
[105] Y-G. Li, H. Liu, Y. Vander Heyden, M. Chen, Z-T. Wang and
Z-B. Hu; Robustness tests on the United States Pharmacopoeia XXVI
HPLC assay for ginsenosides in Asian and American Ginseng using
an experimental design, Analytica Chimica Acta 536 (2005) 29-38
(Impact Factor: 2.210).
[106] T. Baczek, P. Wiczling, M. Marszall, Y. Vander Heyden and
R. Kaliszan; Prediction of peptide retention at different HPLC
conditions from multiple linear regression models, Journal of
Proteome Research 4 (2005) 555-563 (Impact Factor: 5.611).
[107] E. Van Gyseghem, M. Jimidar, R. Sneyers, D. Redlich, E.
Verhoeven, D.L. Massart and Y. Vander Heyden; Orthogonality and
similarity within silica-based reversed-phase chromatographic
systems, Journal of Chromatography A 1074 (2005) 117-131 (Impact
Factor: 2.922).
[108] P. Forlay-Frick, E. Van Gyseghem, K. Heberger and Y. Vander
Heyden, Selection of orthogonal chromatographic systems based
on parametric and non-parametric statistical tests, Analytica
Chimica Acta 539 (2005) 1-10 (Impact Factor: 2.210).
[109] D. Mangelings, M. Maftouh and Y. Vander Heyden; Capillary
electrochromatographic chiral separations with potential for pharmaceutical
analysis, Journal of Separation Science 28 (2005) 691-709 (Impact
Factor: 2.108).
[110] M. Hajimahmoodi, Y. Vander Heyden, N. Sadeghi, B. Jannat,
M.R. Oveisi and S. Shahbazian, Gas-chromatographic fatty-acid
fingerprints and partial least squares modeling as a basis for
the simultaneous determination of edible oil mixtures, Talanta,
66 (2005) 1108-1116 (Impact Factor: 2.091).
[111] B. Dejaegher, J. Smeyers-Verbeke and Y. Vander Heyden, The
variance of screening and supersaturated design results as a measure
for method robustness, Analytica Chimica Acta 544 (2005) 268-279
(Impact Factor: 2.588).
[112] S. Caetano, J. Aires-de-Sousa, M. Daszykowski, Y. Vander
Heyden; Prediction of enantioselectivity using chirality codes
and Classification and Regression Trees, Analytica Chimica Acta
544 (2005) 315-326 (Impact Factor: 2.588).
[113] J. Elek, D. Mangelings, T. Iványi, I. Lázar
and Y. Vander Heyden, Enantioselective capillary electrophoretic
separation of tryptophane- and tyrosine-methylesters in a dual
system with a tetra-oxadiaza-crown ether derivative and a cyclodextrin,
Journal of Pharmaceutical and Biomedical Analysis 38 (2005) 601-608
(Impact Factor: 1.509).
[114] G. Elaut, T. Vanhaecke, Y. Vander Heyden and Vera Rogiers
Spontaneous apoptosis, necrosis, energy status, glutathione levels
and biotransformation capacities of isolated rat hepatocytes in
suspension: effect of the incubation medium; Biochemical Pharmacology
69 (2005) 1829-1838 (Impact Factor: 3.436).
[115] C. Holvoet, Y Vander Heyden and J. Plaizier-Vercammen, Inclusion
complexation of diazepam with different cyclodextrins in formulations
for parenteral use, Die Pharmazie 60/8 (2005) 598-603 (Impact
Factor: 0.587).
[116] R.D. Marini, N. Matthijs, Y. Vander Heyden, J. Smeyers-Verbeke,
P. Dehouck, J. Hoogmartens, P. Silvestre, A. Ceccato, Ph. Goedert,
J. Saevels, C. Herbots, G. Caliaro, R. Herráez-Hernández,
J. Verdú-Andrès, P. Campíns-Falcó,
W. Van de Wauw, J. De Beer, B. Boulanger, P.Chiap, J. Crommen
and Ph. Hubert; Collaborative study of a liquid chromatographic
method for the determination of R-timolol and other related substances
in S-timolol maleate, Analytica Chimica Acta 546 (2005) 182-192
(Impact Factor: 2.588).
[117] A.M. van Nederkassel, V. Vijverman, D.L. Massart and Y.
Vander Heyden, Development of a Ginkgo Biloba fingerprint chromatogram
with UV- and evaporative light scattering detection and optimization
of the evaporative light scattering detector operating conditions,
Journal of Chromatography A 1085 (2005) 230-239 (Impact Factor:
3.359).
[118] M. Maftouh, C. Granier-Loyaux, E. Chavana, J. Marini, A.
Pradines, Y. Vander Heyden and C. Picard; Screening approach for
chiral separation of pharmaceuticals. III. Supercritical fluid
chromatography for analysis and purification in drug discovery;
Journal of Chromatography A 1088 (2005) 67-81 (Impact Factor:
3.359).
[119] E. Deconinck, T. Hancock, D. Coomans, D.L. Massart and Y.
Vander Heyden; Classification of drugs in absorption classes using
the Classification and Regression Trees (CART) methodology; Journal
of Pharmaceutical and Biomedical Analysis 39 (2005) 91-103 (Impact
Factor: 1.509).
[120] S. Caetano, T. De Caesstecker, R. Put, M. Daszykowski, J.
Van Bocxlaer and Y. Vander Heyden; Exploring and modelling the
responses of ESI and APCI ionization techniques based on molecular
descriptors, Analytica Chimica Acta, 550 (2005) 92-106 (Impact
Factor: 2.588).
[121] C. Holvoet, Y. Vander Heyden and J. Plaizier-Vercammen,
Inclusion complexation of lorazepam with different cyclodextrins
suitable for parenteral use, Drug Development and Industrial Pharmacy,
31 (2005) 567-575 (Impact Factor: 0.917).
[122] E. Deconinck, Q.S. Xu, R. Put, D. Coomans, D.L. Massart
and Y. Vander Heyden, Prediction of gastro-intestinal absorption
using Multivariate Adaptive Regression Splines, Journal of Pharmaceutical
and Biomedical Analysis 39 (2005) 1021-1030 (Impact Factor: 1.509).
[123] I. Stanimirova, M. Daszykowski, E. Van Gyseghem, F.F. Bensaid,
M. Lees, J. Smeyers-Verbeke, D.L. Massart and Y. Vander Heyden,
Chemometrical exploration of an isotopic ratio data set of acetylsalicylic
acid, Analytica Chimica Acta 552 (2005) 1-12 (Impact Factor: 2.588).
[124] D. Mangelings, J. Discry, M. Maftouh, D.L. Massart and Y.
Vander Heyden; Strategy for the chiral separation of non-acidic
pharmaceuticals using capillary electrochromatography, Electrophoresis
26 (2005) 3930-3941 (Impact Factor: 3.743).
[125] G. Vivó-Truyols, J.R. Torres-Lapasió, A.M.
van Nederkassel, Y. Vander Heyden and D.L. Massart; Automated
program for deconvolution of multi-overlapped chromatographic
signals. Part I: peak detection; Journal of Chromatography A 1096
(2005) 133-145 (Impact Factor: 3.359).
[126] G. Vivó-Truyols, J.R. Torres-Lapasió, A.M.
van Nederkassel, Y. Vander Heyden and D.L. Massart; Automated
program for peak detection and deconvolution of multi-overlapped
chromatographic signals. Part II: peak model and deconvolution
algorithms; Journal of Chromatography A 1096 (2005) 146-155 (Impact
Factor: 3.359).
[127] A.M. van Nederkassel, M. Daszykowski, D.L. Massart and Y.
Vander Heyden; Prediction of total green tea antioxidant capacity
from chromatograms by multivariate modeling, Journal of Chromatography
A 1096 (2005) 177-186 (Impact Factor: 3.359).
[128] R. Put, E. Van Gyseghem, D. Coomans and Y. Vander Heyden;
Selection of orthogonal reversed-phase HPLC systems by univariate
and auto-associative multivariate regression trees, Journal of
Chromatography A 1096 (2005) 187-198 (Impact Factor: 3.359).
[129] N. Matthijs, M. Maftouh, Y. Vander Heyden; Enantiomeric
impurity determination in capillary electrophoresis using a highly-sulfated
cyclodextrins-based method, in press (Biomedical Chromatography).
[130] E. Van Gyseghem, B. Dejaegher, R. Put, P. Forlay-Frick,
A. Elkihel, M. Daszykowski, K. Héberger, D.L. Massart and
Y. Vander Heyden; Evaluation of chemometric techniques to select
orthogonal chromatographic systems, in press (Journal of Pharmaceutical
and Biomedical Analysis).
[131] A.M. van Nederkassel, C.J. Xu, P. Lancelin, M. Sarraf, J.R.
Desmurs, D.A. McKenzie, N.J. Walton, F. Bensaid, M. Lees, G.J.
Martin, D.L. Massart, J. Smeyers-Verbeke and Y. Vander Heyden,
Chemometric treatment of vanillin fingerprint chromatograms. Effect
of different signal alignments on principal component analysis
plots, in press (Journal of Chromatography A).
Publications without peer review
[1] D.L. Massart and Y. Vander Heyden, What Chemometrics can
do for Separation Science, LC-GC Europe 17 (9) (2004) 467-470.
[2] D.L. Massart and Y. Vander Heyden, From tables to visuals:
Principal Component Analysis, Part 1, LC-GC Europe 17 (11) (2004)
586-591
[3] D.L. Massart and Y. Vander Heyden, From tables to visuals:
Principal Component Analysis, Part 2, LC-GC Europe, 18 (2) (2005)
84-89.
[4] A. Detroyer en Y. Vander Heyden, Snelle screeningstechniek
voor potentiële geneesmiddelen, De Agenda Gynaecologie 39
(2005) 21-23.
[5] A. Detroyer en Y. Vander Heyden, Snelle screeningstechniek
voor potentiële geneesmiddelen, De Agenda Cardio 10 (2005)
18-20.
[6] D.L. Massart, J. Smeyers-Verbeke and Y. Vander Heyden; How
many samples?, LC-GC Europe, 18 (7) (2005) 390-393.
[7] D.L. Massart, J. Smeyers-Verbeke and Y. Vander Heyden; Benchmarking
for analytical methods: the Horwitz curve, LC-GC Europe, 18 (10)
(2005) 528-531.
[8] D. Mangelings, M. Maftouh, D.L. Massart and Y. Vander Heyden,
Generic capillary electrochromatographic screening and optimization
strategies for chiral method development, in press (LC-GC Europe)
[9] A.M. van Nederkassel and Y. Vander Heyden, A strategy for
the development of UV-ELS fingerprints for Ginkgo biloba extracts,
in press (American Laboratory).
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