Vrije Universiteit Brussel


Selected publications

Here, a number of relevant publications, illustrating the research carried out over the last years, is given. A complete list of publications by the FAFY group can be consulted by clicking here.

Toxicological research

  • Vinken M, Decrock E, De Vuyst E, De Bock M, Vandenbroucke RE, De Geest BG, Demeester J, Sanders NN, Vanhaecke T, Leybaert L, Rogiers V.
    Connexin32 hemichannels contribute to the apoptotic-to-necrotic transition during Fasmediated hepatocyte cell death.
    Cell Mol Life Sci . 2010; 67(6):907-18
    | Pubmed citation | publisher site |

  • Fraczek J, van Grunsven LA, Vinken M, Snykers S, Deleu S, Vanderkerken K, Vanhaecke T, Rogiers V.
    Histone deacetylase inhibition and the regulation of cell growth with particular reference to liver pathobiology.
    J Cell Mol Med . 2009; 13(9B): 2990-3005
    | Pubmed citation | publisher site |

  • Snykers S, De Kock J, Rogiers V, Vanhaecke T.
    Role of epigenetics in liver-specific gene transcription, hepatocyte differentiation, and stem cell reprogrammation.
    Stem Cells . 2009; 27(3): 577-605
    | Pubmed citation | publisher site |

  • Snykers S, Henkens T, De Rop E, Vinken M, Fraczek J, De Kock J, De Prins E, Geerts A, Rogiers V, Vanhaecke T.
    Role of epigenetics in liver-specific gene transcription, hepatocyte differentiation, and stem cell reprogrammation.
    J Hepatol . 2009; 51(1): 187-211.
    | Pubmed citation | publisher site |

  • Vinken M, Doktorova T, Decrock E, Leybaert L, Vanhaecke T, Rogiers V.
    Gap junctional intercellular communication as a target for liver toxicity and carcinogenicity.
    Crit Rev Biochem Mol Biol . 2009; 44(4): 201-22.
    | Pubmed citation |

  • Fraczek J, Deleu S, Lukaszuk A, Doktorova T, Tourwé D, Geerts A, Vanhaecke T, Vanderkerken K, Rogiers V.
    Screening of amide analogues of Trichostatin A in cultures of primary rat hepatocytes : search for potent and safe HDAC inhibitors.
    Invest New Drugs . 2009; 27(4): 338-46.
    | Pubmed citation | publisher site |

  • Vinken M, De Rop E, Decrock E, De Vuyst E, Leybaert L, Vanhaecke T, Rogiers V.
    Epigenetic regulation of gap junctional intercellular communication: more than a way to keep cells quiet?
    Biochim Biophys Acta . 2009; 1795(1): 53-61: 1077-88.
    | Pubmed citation | publisher site |

  • Vinken M, Henkens T, De Rop E, Fraczek J, Vanhaecke T, Rogiers V.
    Biology and pathobiology of gap junctional channels in hepatocytes.
    Hepatology . 2008 Mar; 47(3): 1077-88.
    | Pubmed citation | publisher site |

  • Henkens T, Papeleu P, Elaut G, Vinken M, Rogiers V, Vanhaecke T.
    Trichostatin A, a critical factor in maintaining the functional differentiation of primary cultured rat hepatocytes.
    Toxicol Appl Pharmacol. 2007 Jan 1;218(1):64-71.
    | Pubmed citation | publisher site |

  • Snykers S, Vanhaecke T, Papeleu P, Luttun A, Jiang Y, Vander Heyden Y, Verfaillie C, Rogiers V.
    Sequential exposure to cytokines reflecting embryogenesis: the key for in vitro differentiation of adult bone marrow stem cells into functional hepatocyte-like cells.
    Toxicol Sci. 2006 Dec;94(2):330-41.
    | Pubmed citation | publisher site |

  • Vinken M, Henkens T, Vanhaecke T, Papeleu P, Geerts A, Van Rossen E, Chipman JK, Meda P, Rogiers V.
    Trichostatin a enhances gap junctional intercellular communication in primary cultures of adult rat hepatocytes.
    Toxicol Sci. 2006 Jun;91(2):484-92.
    | Pubmed citation | publisher site |

  • Vanhaecke T, Henkens T, Kass GE, Rogiers V.
    Effect of the histone deacetylase inhibitor trichostatin A on spontaneous apoptosis in various types of adult rat hepatocyte cultures.
    Biochem Pharmacol. 2004 Aug 15;68(4):753-60.
    | Pubmed citation | publisher site |

  • Papeleu P, Loyer P, Vanhaecke T, Elaut G, Geerts A, Guguen-Guillouzo C, Rogiers V.
    Trichostatin A induces differential cell cycle arrests but does not induce apoptosis in primary cultures of mitogen-stimulated rat hepatocytes.
    J Hepatol. 2003 Sep;39(3):374-82.
    | Pubmed citation | publisher site |

  • Elaut G, Torok G, Vinken M, Laus G, Papeleu P, Tourwe D, Rogiers V.
    Major phase I biotransformation pathways of Trichostatin a in rat hepatocytes and in rat and human liver microsomes.
    Drug Metab Dispos. 2002 Dec;30(12):1320-8.
    | Pubmed citation | publisher site |

Dermato-cosmetic research

  • Pauwels M, Rogiers V.
    Human health safety evaluation of cosmetics in the EU: A legally imposed challenge to science.
    Toxicol Appl Pharmacol . 2010; 243(2): 260-74.
    | Pubmed citation | publisher site |

  • De Paepe K, Wibaux C, Ward C, Rogiers V.
    Skin efficacy and Biophysical Assessment of Glycerol-Containing Hydrocolloid Patches.
    Skin Pharmacol Physiol . 2009; 22(5): 258-65.
    | Pubmed citation | publisher site |

  • Pauwels M, Dejaegher B, Vander Heyden Y, Rogiers V.
    Critical analysis of the SCCNFP/SCCP safety assessment of cosmetic ingredients (2000-2006).
    Food Chem Toxicol . 2009; 47(4): 898-905.
    | Pubmed citation |

  • De Paepe K, Houben E, Adam R, Hachem JP, Roseeuw D, Rogiers V.
    Seasonal Effects on the Nasolabial Skin Condition.
    Skin Pharmacol Physiol . 2009; 22(1): 8-14.
    | Pubmed citation | publisher site |

  • Houben E, Adam R, Hachem, JP, Roseeuw D, Rogiers V, De Paepe K.
    Clinical scoring and biophysical evaluation of nasolabial skin barrier damage caused by rhinorrhea.
    Contact Dermatitis . 2008; 59(5): 296-300.
    | Pubmed citation | publisher site |

  • Houben E, Hachem JP, De Paepe K, Rogiers V.
    Epidermal ceramidase activity regulates epidermal desquamation via stratum corneum acidification.
    Skin Pharmacol Physiol . 2008; 21(2): 111-8.
    | Pubmed citation |

  • Houben E, De Paepe K, Rogiers V.
    A Keratinocyte's Course of Life.
    Skin Pharmacol Physiol. 2007;20(3):122-32.
    | Pubmed citation | publisher site |

  • Pauwels M, Rogiers V.
    EU legislations affecting safety data availability of cosmetic ingredients.
    Regul Toxicol Pharmacol . 2007 Dec; 49 (3): 308-15.
    | Pubmed citation | publisher site |

  • Hachem JP, Houben E, Crumrine D, Man MQ, Schurer N, Roelandt T, Choi EH, Uchida Y, Brown BE, Feingold KR, Elias PM.
    Serine protease signaling of epidermal permeability barrier homeostasis.
    J Invest Dermatol. 2006 Sep;126(9):2074-86.
    | Pubmed citation | publisher site |

  • Houben E, Holleran WM, Yaginuma T, Mao C, Obeid LM, Rogiers V, Takagi Y, Elias PM, Uchida Y.
    Differentiation-associated expression of ceramidase isoforms in cultured keratinocytes and epidermis.
    J Lipid Res. 2006 May;47(5):1063-70.
    | Pubmed citation | publisher site |

  • Hachem JP, Wagberg F, Schmuth M, Crumrine D, Lissens W, Jayakumar A, Houben E, Mauro TM, Leonardsson G, Brattsand M, Egelrud T, Roseeuw D, Clayman GL, Feingold KR, Williams ML, Elias PM.
    Serine protease activity and residual LEKTI expression determine phenotype in Netherton syndrome.
    J Invest Dermatol. 2006 Jul;126(7):1609-21.
    | Pubmed citation | publisher site |

  • Houben E, De Paepe K, Rogiers V.
    Skin condition associated with intensive use of alcoholic gels for hand disinfection: a combination of biophysical and sensorial data.
    Contact Dermatitis. 2006 May;54(5):261-7.
    | Pubmed citation | publisher site |

  • De Paepe K, Houben E, Adam R, Wiesemann F, Rogiers V.
    Validation of the VapoMeter, a closed unventilated chamber system to assess transepidermal water loss vs. the open chamber Tewameter.
    Skin Res Technol. 2005 Feb;11(1):61-9.
    | Pubmed citation | publisher site |

  • De Paepe K, Weerheim A, Houben E, Roseeuw D, Ponec M, Rogiers V.
    Analysis of epidermal lipids of the healthy human skin: factors affecting the design of a control population.
    Skin Pharmacol Physiol. 2004 Jan-Feb;17(1):23-30.
    | Pubmed citation | publisher site |

  • Pauwels M, Rogiers V.
    Safety evaluation of cosmetics in the EU. Reality and challenges for the toxicologist.
    Toxicol Lett. 2004 Jun 15;151(1):7-17.
    | Pubmed citation | publisher site |

 

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