• Influence and correction of temperature perturbations on NIR spectra during the monitoring of a polymorph conversion process prior to self-modelling mixture analysis
    K. De Braekeleer, F. Cuesta Sánchez, P.A. Hailey, D.C.A. Sharp, A.J. Pettman and D.L. Massart
    Journal of Pharmaceutical and Biomedical Analysis 17 (1998), 141-152

    Abstract :

    A polymorph conversion of species P1 to P2 was monitored on-line by near infrared spectroscopy. Two sets of data measured at constant and varying temperature were considered for the same process. In order to obtain a better comparison of the resolution results a temperature correction was proposed. The resolution of the spectral data in the concentration profiles and the spectra was obtained with SIMPLISMA and OPA.